[The interaction of human natural killers with target cells of the K562 line and its sublines characterized by multiple drug resistance and thermoresistance]

Autor:	T K, Davtian, G I, Blinova, T N, Ignatova, Iu T, Aleksanian, M B, Meliksetian
Rok vydání:	1993
Předmět:	Cell Nucleus Killer Cells Natural Hot Temperature Cell Death Leukemia Myelogenous Chronic BCR-ABL Positive Drug Resistance Tumor Cells Cultured Humans Cell Communication DNA Neoplasm Cytotoxicity Tests Immunologic
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 116(12)
ISSN:	0365-9615
Popis:	Target cells, K562 strain and its sublines characterized by multiple drug resistance (MDR) do not differ in their susceptibility to human natural killer cells (NK) but MDR cells are more susceptible to cytotoxic action of lymphokine-activated cells (LAC) and to NK cells in the presence of a selective agent adriamycin. Target cells death is characterized by fragmentation of nuclear DNA. It has been established that K562 thermotolerant subclone is more resistant to NK and LAC than other clones. Heat shock protein synthesis may have a protective impact in target cells death during interaction with NK and LAC cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e8750ea3793f440b18867726c9961f88 https://pubmed.ncbi.nlm.nih.gov/8123821 Zobrazit plný text záznamu