| Autor: |
C, Castellano, V V, Petkov, R, Kehayov, N, Panusheva |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Acta physiologica et pharmacologica Bulgarica. 15(3) |
| ISSN: |
0323-9950 |
| Popis: |
The newly synthetized cholinesterase inhibitor C-8 (a structural analogue of physostigmine) at a dose of 4 mg.kg-1 exerted no inhibitory effect on the spontaneous locomotor activity in 2-, 10- and 22-month old male Wistar rats. Upon open field test, C-8 facilitated the process of habituation in the rats of all three groups. In a passive avoidance situation (step-down and step-through) C-8 had a favorable effect on the memory of 22-month old rats mainly. C-8 inhibited the cholinesterase activity in the striatum of 2-month old rats by 29%, in 10-month old rats by 73%, and in 22-month old rats by 30%. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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