Short-term effects of TNP-470 in combination with cisplatin in the rat model of bladder cancer
| Autor: | Xianghua, Zhang, Motoki, Yamashita, Hirotsugu, Uetsuki, Yoshiyuki, Kakehi |
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| Rok vydání: | 2002 |
| Předmět: |
Carcinoma
Transitional Cell O-(Chloroacetylcarbamoyl)fumagillol Antibiotics Antineoplastic Microcirculation Angiogenesis Inhibitors Apoptosis DNA Neoplasm Rats Immunoenzyme Techniques Platelet Endothelial Cell Adhesion Molecule-1 Disease Models Animal Ki-67 Antigen Urinary Bladder Neoplasms Cyclohexanes In Situ Nick-End Labeling Animals Drug Therapy Combination Neoplasm Invasiveness Cisplatin Rats Wistar Sesquiterpenes Cell Division |
| Zdroj: | In vivo (Athens, Greece). 16(5) |
| ISSN: | 0258-851X |
| Popis: | To investigate the short-term effects of TNP-470 in combination with cisplatin in a rat model of bladder cancer.Following treatment of TNP-470 with or without cisplatin for 7 days, the states of angiogenesis, apoptosis and cell proliferation were evaluated in rat bladder cancer induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.In comparison with untreated tumors, we noted a significantly decreased microvessel density (MVD) in the rat bladder cancer treated by TNP-470, and a significantly increased apoptotic index (AI) when treated by cisplatin. In TNP-470 plus cisplatin-treated tumors, both significantly decreased MVD and increased AI were observed in non-invasive and invasive rat bladder cancers in addition to a significantly decreased proliferation index (PI) in invasive cancer.The combination therapy of TNP-470 with cisplatin may act through both the inhibition of angiogenesis and induction of apoptosis, and invasive tumor cells may be much more sensitive to this combined therapy in rat bladder cancer. |
| Databáze: | OpenAIRE |
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