| Autor: |
Hui-Ju, Wang, Liang, Wang, Jia, Lv, Luo-Qin, Fu, Zhen, Wang, Xiang-Lei, He, Ying-Yu, Ma, Li, Li, Tong-Wei, Zhao, Xiao-Gang, Xu, Li-Li, Yu, Hong-Ying, Pan, Zhi-Ming, Hu, Xiao-Zhou, Mou |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
International journal of clinical and experimental pathology. 10(10) |
| ISSN: |
1936-2625 |
| Popis: |
Background and aim: ZW10 interacting kinetochore protein 1 (Zwint-1), one of the major kinetochore proteins, is essential for kinetochore function, such as spindle assembly checkpoint function and kinetochore-microtubule attachment. Recently, it has been found over-expressed in some human cancers, including ovarian cancer, bladder cancer, and pulmonary adenocarcinoma. However, few studies of the expression of Zwint-1 in hepatocellular carcinoma (HCC) have been reported. This study is aimed to investigate the expression of Zwint-1 and its relationship with clinical pathological characters in HCC. Methods: The expression of Zwint-1 protein was analyzed by immunohistochemistry staining on tissue microarrays containing 171 HCC tissues and 187 control non-tumorous liver tissues. The relationships between the Zwint-1 expression and the clinicopathological parameters, and survival analysis were investigated using SPSS software 13.0. Results: Zwint-1 was found uniformly expressed in adjacent non-tumorous liver tissues (184/187, 98.40%), while was significantly decreased in HCC tissues, or even absent (150 of 171, 61.82%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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