Genomic epidemiology of nontoxigenic
| Autor: | Lingzi, Xiaoli, Eileen, Benoliel, Yanhui, Peng, Janessa, Aneke, Pamela K, Cassiday, Meagan, Kay, Shelly, McKeirnan, Jeffery S, Duchin, Vance, Kawakami, Scott, Lindquist, Anna M, Acosta, Chas, DeBolt, Maria Lucia, Tondella, Michael R, Weigand |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Washington nontoxigenic Corynebacterium Infections Whole Genome Sequencing Outbreak Report Virulence Factors Corynebacterium diphtheriae High-Throughput Nucleotide Sequencing SNP Middle Aged Polymorphism Single Nucleotide virulence factor C. diphtheriae Disease Outbreaks Microbial evolution and epidemiology: Communicable disease genomics Ill-Housed Persons genomics Humans Female Phylogeny Aged |
| Zdroj: | Microbial Genomics |
| ISSN: | 2057-5858 |
| Popis: | Between July 2018 and May 2019, Corynebacterium diphtheriae was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic C. diphtheriae biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available C. diphtheriae genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic C. diphtheriae . |
| Databáze: | OpenAIRE |
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