Interleukin-10 receptor signaling promotes the maintenance of a PD-1

Autor:	Bola S, Hanna, Laura, Llaó-Cid, Murat, Iskar, Philipp M, Roessner, Lara C, Klett, John K L, Wong, Yashna, Paul, Nikolaos, Ioannou, Selcen, Öztürk, Norman, Mack, Verena, Kalter, Dolors, Colomer, Elías, Campo, Johannes, Bloehdorn, Stephan, Stilgenbauer, Sascha, Dietrich, Manfred, Schmidt, Richard, Gabriel, Karsten, Rippe, Markus, Feuerer, Alan G, Ramsay, Peter, Lichter, Marc, Zapatka, Martina, Seiffert
Rok vydání:	2021
Předmět:	STAT3 Transcription Factor NFATC Transcription Factors Programmed Cell Death 1 Receptor Immunity CD8-Positive T-Lymphocytes Leukemia Lymphocytic Chronic B-Cell Mice Inbred C57BL Transcription Factor AP-1 Mice Cellular Microenvironment T-Lymphocyte Subsets Cell Line Tumor Animals Humans Receptors Interleukin-10 Hepatocyte Nuclear Factor 1-alpha Immunotherapy Cells Cultured Signal Transduction
Zdroj:	Immunity. 54(12)
ISSN:	1097-4180
Popis:	T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e7d083f208fa077095390dc49708bdbd https://pubmed.ncbi.nlm.nih.gov/34879221 Zobrazit plný text záznamu