| Autor: |
F, Akram, D, Fuchs, M, Daue, G, Nijjar, A, Ryan, M E, Benros, O, Okusaga, E, Baca-Garcia, L A, Brenner, C A, Lowry, K A, Ryan, M, Pavlovich, B D, Mitchell, S, Snitker, T T, Postolache |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Obesity Science & Practice |
| ISSN: |
2055-2238 |
| Popis: |
Summary Objectives Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods Fasting nitrite levels were measured in 116 Old Order Amish (78% women). We performed age‐and‐sex‐adjusted ancovas to compare nitrite levels between three groups (a) overweight/obese(−)MetS(−), (b) overweight/obese(+)MetS(−) and (c) overweight/obese(+)MetS)(+). Multivariate linear regressions were conducted on nitrite associations with continuous metabolic variables, with successive adjustments for demographics, body mass index, C‐reactive protein and neopterin. Results Nitrite levels were higher in the obese/overweight(+)MetS(+) group than in the other two groups (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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