| Autor: |
S, Watanabe, Y, Yamaguchi, M, Hattori, H, Chikamoto, N, Matsumoto, T, Suzuki, M, Oonishi, S, Horita, T, Tokumoto, K, Tanabe, H, Shiraga, H, Toma, K, Ito |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Clinical transplantation. 14 |
| ISSN: |
0902-0063 |
| Popis: |
Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmacokinetics are highly variable. We experienced a case of acute nephrotoxicity, in which the blood level rose about 10 times above the expected level. We found a peculiar vacuolization in the transplant biopsy specimen. This change showed a marked vacuolization of the tubular cells, suggestive of acute nephrotoxicity by TAC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
