Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1

Autor:	Ryan J, Seelbach, Peter, Fransen, Daniel, Pulido, Matteo, D'Este, Fabian, Duttenhoefer, Sebastian, Sauerbier, Thomas M, Freiman, Philipp, Niemeyer, Fernando, Albericio, Mauro, Alini, Miriam, Royo, Alvaro, Mata, David, Eglin
Rok vydání:	2015
Předmět:	Dendrimers Magnetic Resonance Spectroscopy Bone Morphogenetic Protein 2 Hydrogels Transforming Growth Factor beta1 Drug Delivery Systems Delayed-Action Preparations Humans Nanotechnology Amino Acids Hyaluronic Acid Peptides Rheology Protein Binding
Zdroj:	Macromolecular bioscience. 15(8)
ISSN:	1616-5195
Popis:	BMP-2 and TGF-β1 released from injectable thermoresponsive hydrogels are studied in the presence and absence of branched macromolecules bearing BMP-2 or TGF-β1 affinity binding peptides. The synthesized branched macromolecules and the gelling compositions before and after loading with either BMP-2 or TGF-β1 are characterized physico-chemically and show a significantly lower amount of proteins released in the presence of the affinity binding peptide macromolecules. This study illustrates the potential of affinity binding peptide functionalized dendrimers to modulate the local delivery and availability of growth factors important for musculoskeletal regeneration therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e7a96e2f0606197a00bc86bbbe9a902a https://pubmed.ncbi.nlm.nih.gov/25943094 Zobrazit plný text záznamu Plný text