Radiation and chemotherapy. Treatment of localized pancreatic carcinoma
| Autor: | P H, Blitzer, D E, Dosoretz, M J, Katin, J H, Rubenstein, W N, Harwin, M G, Raymond, T E, Teufel, L, Seidenstein, M M, Mangano, S A, Salenius |
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| Rok vydání: | 1994 |
| Předmět: |
Aged
80 and over Male Leucovorin Adenocarcinoma Middle Aged Combined Modality Therapy Streptozocin Carboplatin Pancreatic Neoplasms Radiotherapy High-Energy Survival Rate Chemotherapy Adjuvant Doxorubicin Antineoplastic Combined Chemotherapy Protocols Humans Female Fluorouracil Cisplatin Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | The Journal of the Florida Medical Association. 81(6) |
| ISSN: | 0015-4148 |
| Popis: | Patients unable to undergo a pancreatoduodenectomy for adenocarcinoma of the pancreas are often treated with radiation therapy. A randomized trial by the Gastrointestinal Tumor Study Group has shown an advantage in combining it with chemotherapy. A similar size retrospective study at a large community radiation therapy center assessed this finding in the nonprotocol setting. The study population consisted of 86 patients treated with primary radiation therapy between 1982 and 1992; 62 of them also received chemotherapy. The overall probability of survival was 39% and 13% at 12 and 24 months respectively. Patients receiving chemotherapy had a significantly (p = .018) longer survival (44% versus 25% at 12 months). Results confirm the Study Group's findings and suggest that they be applied to the community setting. |
| Databáze: | OpenAIRE |
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