A prospective evaluation of clinical and genetic predictors of weight changes in breast cancer survivors
| Autor: | Maureen, Sadim, Yanfei, Xu, Katharina, Selig, Julie, Paulus, Regina, Uthe, Surbhi, Agarwl, Iram, Dubin, Panagiota, Oikonomopoulou, Lesya, Zaichenko, Silvia Aki, McCandlish, Linda, Van Horn, Christos, Mantzoros, Donna Pauler, Ankerst, Virginia G, Kaklamani |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Aged 80 and over Leptin Antineoplastic Agents Hormonal Genotype Radiotherapy Alpha-Ketoglutarate-Dependent Dioxygenase FTO Antineoplastic Agents Breast Neoplasms Middle Aged Weight Gain Polymorphism Single Nucleotide Body Mass Index Fibronectins Risk Factors Humans Anthracyclines Female Adiponectin Obesity Prospective Studies Survivors Receptors Adiponectin Aged Neoplasm Staging |
| Zdroj: | Cancer. 123(13) |
| ISSN: | 1097-0142 |
| Popis: | Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions.The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint. Demographics, clinical factors, treatment methods, as well as tumor characteristics were also recorded; and a lifestyle questionnaire was conducted. Blood samples were genotyped for 16 single nucleotide polymorphisms in FTO, adiponectin pathway genes (ADIPOQ, ADIPOR1), and FNDC5. Serum leptin, adiponectin, and irisin levels also were measured.Mean ± standard deviation 18-month BMI changes were 0.68 ± 1.42, 0.98 ± 1.62, 0.79 ± 1.74, and -0.44 ± 1.58 kg/mWomen age 60 years and younger at the time of breast cancer diagnosis who have an obesity genetic risk model are at increased risk for weight gain after treatment and should be targeted for weight-maintenance interventions. Cancer 2017;123:2413-21. © 2017 American Cancer Society. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text