Effects of Prunus mume Sieb. et Zucc. extract and its biopolymer encapsulation on a mouse model of colitis
| Autor: | Seung Yun, Lee, Seung-Jae, Lee, Sun Jin, Hur |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Mice Inbred BALB C Colon Food Handling Plant Extracts Anti-Inflammatory Agents Non-Steroidal Dextran Sulfate Free Radical Scavengers Organ Size Inflammatory Bowel Diseases Weight Gain Antioxidants Disease Models Animal Random Allocation Biopolymers Gastrointestinal Agents Fruit Animals Prunus Intestinal Mucosa |
| Zdroj: | Journal of the science of food and agriculture. 97(2) |
| ISSN: | 1097-0010 |
| Popis: | Prunus mume suppresses various diseases caused by inflammation response and exhibits antioxidant and free radical-scavenging activities. Therefore this study determined the effect of an aqueous P. mume (PM) extract in a mouse colitis model and investigated the value of biopolymer encapsulation, facilitating targeted delivery to the colon. Colitis was induced by administration of 30 g kgHistological examination of the colon in BALB/c mice showed epithelial destruction and mucosal infiltration of inflammatory cells. These changes were attenuated in PM-treated mice, which had lower levels of inflammatory cytokines, cyclooxygenase 2 and immunoglobulins (IgA, IgM and IgE) compared with the vehicle-treated colitis group. The PM extract showed concentration-dependent radical scavenging and superoxide dismutase-like antioxidant activities.These results indicated that the effects of the PM extract on colitis were not influenced by biopolymer encapsulation and that this PM extract could be a potential therapeutic agent for inflammatory bowel disease. © 2016 Society of Chemical Industry. |
| Databáze: | OpenAIRE |
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