| Autor: |
Alessio, Imperiale, Caroline, Boursier, Nicolas, Sahakian, Eric, Ouvrard, Elodie, Chevalier, Frédéric, Sebag, Pietro, Addeo, David, Taïeb |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
J Nucl Med |
| ISSN: |
1535-5667 |
| Popis: |
Our objective was to assess the value of (68)Ga-DOTATOC and carbidopa-assisted (18)F-fluorodihydroxyphenylalanine ((18)F-DOPA) in 21 hypoglycemic patients. Methods: All patients who underwent (68)Ga-DOTATOC or carbidopa-assisted (18)F-DOPA PET/CT for suspicion of insulinoma from January 2019 to January 2021 were retrospectively analyzed. A final diagnosis of insulinoma was determined by pathologic reports or consensus. Results: During the study period, 21 patients underwent both (68)Ga-DOTATOC and (18)F-DOPA PET/CT. A final diagnosis of insulin-secreting tumor was reached in 12 cases, including 11 insulinomas and 1 small mixed neuroendocrine/nonneuroendocrine neoplasm. (18)F-DOPA and (68)Ga-DOTATOC PET/CT were positive in 5 (45%) and 7 (64%) of 11 cases, respectively, with 4 concordant positive findings. Moreover, 1 insulinoma was visualized exclusively by (18)F-DOPA PET/CT and 3 by (68)Ga-DOTATOC PET/CT only. (18)F-DOPA and (68)Ga-DOTATOC PET/CT were falsely positive in 1 nonfunctioning pancreatic neuroendocrine tumor. Conclusion: When (68)Ga-exendin-4 is not available, (68)Ga-somatostatin receptor PET/CT should be the first choice for insulinoma functional imaging. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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