| Popis: |
Effects ofverapamil, a slow calcium channel blocker, on the production of anti-inflammatory cytokines (TNF-alpha and IL-beta) by peritoneal mononuclears were studied using a rat model of aseptic intra-abdominal inflammation. Autohemoperitoneum was simulated by intraperitoneal administration of autoblood (group 1). The similarly treated animals of group 2 were additionally given verapamil. A statistically significant rise in the TNF-alpha and IL-beta levels was documented in the former case. In group 2, verapamil substantially modified functional activity of peritoneal macrophages in that TNF-alpha content in peritoneal exudate was twice lower than in group 1 while the IL-beta level remained unaltered. These findings suggest that slow calcium channels are involved in regulation of cytokine-producing function of mononuclear cells during intra-abdominal inflammation. |
