Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis
| Autor: | Liu, Yun, Wang, Guanghui, Liang, Zhonglin, Mei, Zubing, Wu, Tingyu, Cui, Ang, Liu, Chenying, Cui, Long |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Male Lung Neoplasms endocrine system diseases Muscle Proteins Cell Cycle Proteins Disease-Free Survival Protein-Lysine 6-Oxidase Biomarkers Tumor Humans hepatic metastasis Aged Cell Proliferation integumentary system lung metastasis Liver Neoplasms food and beverages Nuclear Proteins TEA Domain Transcription Factors Original Articles Middle Aged HCT116 Cells Prognosis Colorectal cancer Carcinoembryonic Antigen DNA-Binding Proteins Gene Expression Regulation Neoplastic enzymes and coenzymes (carbohydrates) Gene Knockdown Techniques Lymphatic Metastasis Original Article Female lysyl oxidase Colorectal Neoplasms Transcription Factors |
| Zdroj: | Thoracic Cancer |
| ISSN: | 1759-7714 1759-7706 |
| Popis: | Background Colorectal cancer (CRC) is a common and lethal disease in which distant metastasis remains the primary cause of death. Paradoxical roles of LOX have been reported in CRC, and the intracellular function of LOX has also recently been determined. Correlations of LOX expression and its intracellular localization with clinicopathological features in CRC patients remain largely unknown. The aim of the present study was to explore the potential roles of LOX in CRC. Methods LOX messenger RNA expression was assayed by quantitative PCR in eight paired normal mucosa and tumor tissues. Immunohistochemistry was conducted using tissue arrays to investigate LOX expression in 201 CRC patients. Regulation of LOX by YAP and TEAD4 was explored by YAP or TEAD4 short hairpin RNA interference in a LoVo cell line. Results LOX messenger RNA expression was elevated in some CRC specimens, and LOX nuclear localization was detected in CRC tumor tissues. LOX nuclear localization was found to correlate with lung/hepatic metastasis, elevated serum carcinoembryonic antigen concentration, and mucinous tumor type (P |
| Databáze: | OpenAIRE |
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