| Autor: |
D, De Craemer, F, Roels, C, Van den Branden |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
European journal of morphology. 31(1-2) |
| ISSN: |
0924-3860 |
| Popis: |
We investigated hepatic catalase activity, and morphologic and morphometric alterations of hepatocellular peroxisomes after catalase cytochemistry, in mice given a diet supplemented with 10% Beromegan, a commercial fish oil preparation, for up to three days. Fish oil is rich in docosahexaenoic acid (C22:6 (n-3)) and in eicosapentaenoic acid (20:5 (n-3)). Hepatic catalase activity showed a gradual increase in mice fed this diet, being significantly increased (136 +/- 10 UB/g liver) after three days when compared top controls (85 +/- 11 UB/g liver). Light microscopy indicated an increase in peroxisomal staining and peroxisomal proliferation. The latter observation was confirmed by ultrastructural morphometry: number, volume density and surface density of the peroxisomes were more than doubled after a three day diet containing fish oil. Peroxisomal size was not changed. These alterations are suggestive for an increased peroxisomal metabolism induced by a diet rich in poly-unsaturated fatty acids. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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