[Isolation of the fragment D dimer from stabilized fibrin and a study of its antipolymerization action]

Autor: A A, Musialkovskaia, E L, Khodorova, T M, Pozdniakova
Rok vydání: 1976
Předmět:
Zdroj: Ukrains'kyi biokhimichnyi zhurnal. 48(2)
ISSN: 0041-610X
Popis: The dimer of fragment D is isolated preparatively by CM-cellulose chromatography (in neutral medium) from dialyzed tryptic hydrolyzate of stabilized fibrin. Contrary to the fragment D monomer obtained from fibrinogen under the same conditions, the dimer itself cannot inhibit polymerization of monomeric fibrin. However with the presence of monomer D in the amount sufficient for essential inhibition of the fibrin polymerization the addition of dimer D produces the further delay in polymerization. Under these conditions dimer D is highly effective inhibitor if its amount is not too little, as its small doses are not effective.
Databáze: OpenAIRE