| Autor: |
Ana Paula, Ferraz, Fernando A C, Seara, Emanuelle F, Baptista, Thais S, Barenco, Thais B B, Sottani, Natalia S C, Souza, Ainá E, Domingos, Raiana A Q, Barbosa, Christina M, Takiya, Marcos T, Couto, Gabriel O, Resende, Antonio C, Campos de Carvalho, Cristiano G, Ponte, Jose Hamilton M, Nascimento |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Cardiovascular drugs and therapy. 35(4) |
| ISSN: |
1573-7241 |
| Popis: |
In the present study, the therapeutic efficacy of a selective BKPAH was induced in male Wistar rats by a single injection of MCT. After two weeks, the MCT-treated group was divided into two groups that were either treated with compound X or vehicle. Compound X was administered daily at 28 mg/kg. Electrocardiographic, echocardiographic, and haemodynamic analyses were performed; ex vivo evaluations of pulmonary artery reactivity, right ventricle (RV) and lung histology as well as expression levels of α and β myosin heavy chain, brain natriuretic peptide, and cytokines (TNFα and IL10) in heart tissue were performed.Pulmonary artery rings of the PAH group showed a lower vasodilatation response to acetylcholine, suggesting endothelial dysfunction. Compound X promoted strong vasodilation in pulmonary artery rings of both control and MCT-induced PAH rats. The untreated hypertensive rats presented remodelling of pulmonary arterioles associated with increased resistance to pulmonary flow; increased systolic pressure, hypertrophy and fibrosis of the RV; prolongation of the QT and TThe use of a selective and potent opener to activate the BK |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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