In Vivo Imaging of the Programmed Death Ligand 1 by
| Autor: | Dinko E, González Trotter, Xiangjun, Meng, Paul, McQuade, Daniel, Rubins, Michael, Klimas, Zhizhen, Zeng, Brett M, Connolly, Patricia J, Miller, Stacey S, O'Malley, Shu-An, Lin, Krista L, Getty, Laurence, Fayadat-Dilman, Linda, Liang, Elisabet, Wahlberg, Olof, Widmark, Caroline, Ekblad, Fredrik Y, Frejd, Eric D, Hostetler, Jeffrey L, Evelhoch |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Fluorine Radioisotopes Antibodies Monoclonal Affinity Labels Mice SCID Neoplasms Experimental Surface Plasmon Resonance Immunohistochemistry B7-H1 Antigen Isotope Labeling Positron-Emission Tomography Organometallic Compounds Animals Autoradiography Humans Female Tissue Distribution Radiopharmaceuticals |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 58(11) |
| ISSN: | 1535-5667 |
| Popis: | Programmed death ligand 1 (PD-L1) is an immune regulatory ligand that binds to the T-cell immune check point programmed death 1. Tumor expression of PD-L1 is correlated with immune suppression and poor prognosis. It is also correlated with therapeutic efficacy of programmed death 1 and PD-L1 inhibitors. In vivo imaging may enable real-time follow-up of changing PD-L1 expression and heterogeneity evaluation of PD-L1 expression across tumors in the same subject. We have radiolabeled the PD-L1-binding Affibody molecule NOTA-Z |
| Databáze: | OpenAIRE |
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