| Autor: |
Yoko, Niki, Naoko, Adachi, Masaki, Fukata, Yuko, Fukata, Shinichiro, Oku, Chieko, Makino-Okamura, Seiji, Takeuchi, Kazumasa, Wakamatsu, Shosuke, Ito, Lieve, Declercq, Daniel B, Yarosh, Tomas, Mammone, Chikako, Nishigori, Naoaki, Saito, Takehiko, Ueyama |
| Rok vydání: |
2022 |
| Zdroj: |
The Journal of investigative dermatology. |
| ISSN: |
1523-1747 |
| Popis: |
Palmitoylation is a lipid modification involving the attachment of palmitic acid to a cysteine residue, thereby affecting protein function. We investigated the effect of palmitoylation of tyrosinase, the rate-limiting enzyme in melanin synthesis, using a human three-dimensional skin model system and melanocyte culture. The palmitoylation inhibitor, 2-bromopalmitate, increased melanin content and tyrosinase protein levels in melanogenic cells by suppressing tyrosinase degradation. The palmitoylation site was Cysteine |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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