| Autor: |
K, Andrabi, N, Kaul, N K, Ganguly, J B, Dilawari |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Biochemistry international. 18(6) |
| ISSN: |
0158-5231 |
| Popis: |
In situ perfusion of rat liver with carbon tetrachloride (10-15 mM at a final concentration of lul/ml of mineral oil) resulted in a significant (p less than 0.01) loss of microsomal Ca2+ over 5-15 min of exposure. Mitochondrial Ca2+ content increased sharply (2 fold) with concomitant increase in the cytosolic free Ca2+. The changes were associated with a significant (p less than 0.01) decrease in plasma membrane Ca2+ - ATPase activity, reflected by impaired Ca2+ efflux and Ca2+ exchange properties. Our data indicates that impairment of plasma membrane Ca2+ flux contributes substantially to the overall disruption of calcium homeostasis induced by carbon tetrachloride. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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