| Autor: |
E E, Tzoracoleftherakis, J D, Spiliotis, T, Kyriakopoulou, S K, Kakkos |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Hepato-gastroenterology. 46(26) |
| ISSN: |
0172-6390 |
| Popis: |
To compare intra-arterial (regional) hepatic chemotherapy with doxorubicin, to the systemic (intravenous) one in patients with non-resectable (Stage IVA) hepatocellular carcinoma.Seventy-two patients with inoperable hepatocellular carcinoma were randomized to receive doxorubicin 50 mg/m2 as a bolus infusion either via an implantable intra-arterial catheter (Group A) or as systemic chemotherapy (Group B) every 21-28 days.Patients of Group A had a higher rate of objective and subjective remissions and Karnofsky performance status improvement in comparison to Group B. The mean survival was 7 months (range: 2-16) for Group A and 6.5 months (range: 1-13) for Group B, but this difference was not statistically significant. The quality of life remained at an acceptable level until death in both groups.A slight but not statistically significant superiority of intra-arterial chemotherapy against the systemic one is concluded. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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