| Autor: |
A, Kharchafi, Z, Oualim, T, Amezyane, F, Mahassin, D, Ghafir, V, Ohayon, M I, Archane |
| Jazyk: |
francouzština |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
La Revue de medecine interne. 23(6) |
| ISSN: |
0248-8663 |
| Popis: |
The main issue in venous thrombotic events is their etiology. Several clinical and/or biological data can be helpful in that research. In the two cases we report here, a macrocytic anemia led to the diagnosis of probably acquired hyperhomocysteinemia.a 24-year-old man was admitted for severe anemia and a superior vena cava syndrome. Biological data showed megaloblastic anemia and mild features of blood destruction that were explained by a pernicious anemia. Second case: a 35-year-old man had two deep venous thrombotic events in one year (involving the right leg, then the left leg); biological findings showed a macrocytic mild anemia that was diagnosed as a pernicious anemia. In both of the patients, deep venous thrombosis was mainly explained by a hyperhomocysteinemia that was a consequence of vitamin B12 deficiency. The two patients improved under anticoagulant treatment combined with subcutaneous vitamin B12.Pernicious anemia can cause acquired hyperhomocysteinemia, which is considered a risk factor for deep venous thrombosis. Thus, the connectivity of these conditions should remain in the practitioner's mind, especially when thrombosis occurs along with a macrocytic anemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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