| Autor: |
N I, Andrzheiuk, N A, Smirnova, S E, Narovlianskaia, V P, Novoselova, E G, Kruglova |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Problemy tuberkuleza. (8) |
| ISSN: |
0032-9533 |
| Popis: |
As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue. Two mechanisms of isoniazid's pro-fibrotic action are presented. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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