| Autor: |
P F, Klein-Weigel, C, Köning, A, Härtwig, K, Krüger, B, Gutsche-Petrak, S, Dreusicke, U, Thieme, K, Enke-Melzer, B, Urbach, J, Kron |
| Jazyk: |
němčina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Zentralblatt fur Chirurgie. 137(5) |
| ISSN: |
1438-9592 |
| Popis: |
Thrombangiitis obliterans or Buerger's disease is a segmental inflammatory disease affecting small and medium-sized veins and arteries, which most often affects young smokers leading to thrombophlebitis and acral ischaemic syndromes, inducing high amputation rates. Based on positive results of a former pilot study we report on our results of immunoadsorption (IA) in clinical routine care, where IA was offered as a treatment option.The uncontrolled course of 12 consecutive TAO-patients treated by IA on a series of 5 consecutive days was observed. Follow-up period was 14.1 (ranging from 1-26) months.Eight patients were treated with one, four patients completed 2 IA-series. In 9 patients an early onset and lasting clinical improvement and an improvement of ischaemia was noted. The intake of pain-relievers (especially opioids) sank drastically. Eight patients returned to work. Retrospectively, in two out of three treatment failures the correct diagnosis of TAO was questionable.IA seems to be a promising treatment option for patients suffering from TAO which should be further evaluated in controlled clinical trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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