| Autor: |
W, Hao, H-Z, Liu, L-G, Zhou, Y-J, Sun, H, Su, J-Q, Ni, T, He, P, Shi, X, Wang |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
European review for medical and pharmacological sciences. 23(9) |
| ISSN: |
2284-0729 |
| Popis: |
To explore the regulatory mechanism of micro-ribonucleic acid (miR)-122-3p in the osteogenic differentiation of mouse adipose-derived stem cells (mADSCs).The regulatory mechanism of miR-122-3p in the osteogenic differentiation of mesenchymal stem cells was investigated through its overexpression and knockdown.The overexpression of miR-122-3p inhibited the osteogenic differentiation of mADSCs. On the contrary, its knockdown promoted the osteogenic differentiation of mADSCs. The further study on the molecular mechanism of miR-122-3p regulating mADSCs' osteogenic differentiation showed that the overexpression of miR-122-3p could activate the Wingless and int-1 (WNT)/β-catenin signaling pathway, but the knockdown of miR-122-3p could repress this signaling pathway.MiR-122-3p influences the osteogenic differentiation of mADSCs by modulating the WNT/β-catenin signaling pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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