| Autor: |
Tomoko, Horinouchi, Kaori, Maeyama, Masashi, Nagai, Masami, Mizobuchi, Yasuko, Takagi, Yuka, Okada, Takeshi, Kato, Mio, Nishimura, Yoko, Kawasaki, Mieko, Yoshioka, Satoshi, Takada, Hisayuki, Matsumoto, Yuji, Nakamachi, Jun, Saegusa, Sachiyo, Fukushima, Kazumichi, Fujioka, Kazumi, Tomioka, Hiroaki, Nagase, Kandai, Nozu, Kazumoto, Iijima, Noriyuki, Nishimura |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of autism and developmental disorders. 52(2) |
| ISSN: |
1573-3432 |
| Popis: |
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G A), and UGT1A1*27 (c.686 C A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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