| Autor: |
Fernando L, Primo, Marcilene M A, Rodrigues, Andreza Ribeiro, Simioni, Zulmira G M, Lacava, Paulo C, Morais, Antonio C, Tedesco |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Journal of nanoscience and nanotechnology. 8(11) |
| ISSN: |
1533-4880 |
| Popis: |
In this study a magnetic nanoemulsion (MNE) was developed from a mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based magnetic fluid, for entrapment of Zn(II)-Phthalocyanine (ZnPc), the latter a classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability was evaluated as a function of time using photocorrelation spectroscopy (PCS) for determination of the average hydrodynamic diameter, diameter dispersion and zeta potential. The ZnPc-loaded magneto nanoemulstion (ZnPc/MNE) formulation was evaluated in vitro assays to access the phototoxicity and the effect of application of AC magnetic fields (magnetohyperthermia damage) after incubation with J774-A1 macrophages cells. Darkness toxicity, phototoxicity and AC magnetic field exposures revealed an enhancement response for combined photodynamic and magnetohyperthermia (MHT) processes, indicating the presence of the synergic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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