Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience

Autor:	Marios C, Panayi, Thomas, Boerner, Thomas, Jahans-Price, Anna, Huber, Rolf, Sprengel, Gary, Gilmour, David J, Sanderson, Paul J, Harrison, Mark E, Walton, David M, Bannerman
Rok vydání:	2021
Zdroj:	Molecular psychiatry.
ISSN:	1476-5578
Popis:	Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic dysfunction and impairments in synaptic plasticity in the etiology of schizophrenia, including deficits associated with the GluA1 AMPAR subunit. GluA1 knockout (Gria1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e4b1fec175927cd137ec9645bab30ae9 https://pubmed.ncbi.nlm.nih.gov/36460723 Zobrazit plný text záznamu Full text from SpringerLink