Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Autor:	Michael A, Gorman, Christine A, Seers, Belinda J, Michell, Susanne C, Feil, N Laila, Huq, Keith J, Cross, Eric C, Reynolds, Michael W, Parker
Rok vydání:	2014
Předmět:	Models Molecular stomatognathic diseases Cysteine Endopeptidases Protein Conformation Bacteroidaceae Infections Gingipain Cysteine Endopeptidases Humans Oral Health Adhesins Bacterial Crystallography X-Ray Protein Structure Reports Porphyromonas gingivalis
Zdroj:	Protein science : a publication of the Protein Society. 24(1)
ISSN:	1469-896X
Popis:	The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 Å resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e4ae6e1bad5a8d96d1f23ff7b8874a8e https://pubmed.ncbi.nlm.nih.gov/25327141 Zobrazit plný text záznamu Plný text