| Autor: |
M B, Tang, T M, Chin, C K, Yap, S K, Ng |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Annals of the Academy of Medicine, Singapore. 32(5) |
| ISSN: |
0304-4602 |
| Popis: |
We describe an interesting patient with penicillamine-induced dermopathy.A 49-year-old woman presented with a 1-year history of recurrent haemorrhagic blisters, milia and purpura over both her elbows, while on long-term penicillamine therapy (1.5 g daily) for Wilson's disease. Histologically, dermal elastin fibres were markedly reduced in the affected areas, consistent with penicillamine-induced elastolysis.The patient's lesions improved significantly after reduction of her penicillamine dose to 500 mg daily.The cutaneous side effects of long-term penicillamine therapy are important to recognise as they may be associated with significant morbidity and may be markers of more ominous underlying systemic elastic fibre damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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