| Autor: |
Paul, Lee, Rita, Yim, Kai-Kei, Miu, Sin-Hang, Fung, Jason Jinyue, Liao, Zhangting, Wang, Jun, Li, Yammy, Yung, Hiu-Tung, Chu, Pui-Kwan, Yip, Emily, Lee, Eric, Tse, Yok-Lam, Kwong, Harinder, Gill |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International journal of molecular sciences. 23(10) |
| ISSN: |
1422-0067 |
| Popis: |
In myelodysplastic syndrome (MDS), resistance to hypomethylating agents (HMA) portends a poor prognosis, underscoring the importance of understanding the molecular mechanisms leading to HMA-resistance. In this study, P39 and Kasumi-1 cells and their azacitidine-resistant and decitabine-resistant sublines were evaluated comparatively with transcriptomic and methylomic analyses. Expression profiling and genome-wide methylation microarray showed downregulation of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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