Veratridine binding to a transmembrane helix of sodium channel Na
| Autor: | Ai, Niitsu, Ayako, Egawa, Keisuke, Ikeda, Kazuo, Tachibana, Toshimichi, Fujiwara |
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| Rok vydání: | 2018 |
| Předmět: |
Protein Conformation
alpha-Helical Veratridine Binding Sites Lipid Bilayers Muscle Proteins Peptide Fragments Sodium Channels Rats Molecular Docking Simulation Protein Domains Animals Amino Acid Sequence Carbon-13 Magnetic Resonance Spectroscopy Dimyristoylphosphatidylcholine Nuclear Magnetic Resonance Biomolecular Protein Binding |
| Zdroj: | Bioorganicmedicinal chemistry. 26(21) |
| ISSN: | 1464-3391 |
| Popis: | The multi-step ligand action to a target protein is an important aspect when understanding mechanisms of ligand binding and discovering new drugs. However, structurally capturing such complex mechanisms is challenging. This is particularly true for interactions between large membrane proteins and small molecules. One such large membrane of interest is Na |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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