Sphingomyelin-degrading pathways in human cells role in cell signalling

Autor:	T, Levade, N, Andrieu-Abadie, B, Ségui, N, Augé, M, Chatelut, J P, Jaffrézou, R, Salvayre
Rok vydání:	2000
Předmět:	Sphingomyelin Phosphodiesterase Animals Humans Ceramides Second Messenger Systems Sphingomyelins
Zdroj:	Chemistry and physics of lipids. 102(1-2)
ISSN:	0009-3084
Popis:	The ubiquitous sphingophospholipid sphingomyelin (SM) can be hydrolysed in human cells to ceramide by different sphingomyelinases (SMases). These enzymes exert a dual role, enabling not only the turnover of membrane SM and the degradation of exogenous (lipoprotein) SM, but also the signal-induced generation of the lipid second messenger ceramide. This review focuses on the function(s) of the different SMases in living cells. While both lysosomal and non-lysosomal pathways that ensure SM hydrolysis in intact cells can be distinguished, the precise contribution of each of these SM-cleaving enzymes to the production of ceramide as a signalling molecule remains to be clarified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e43276e2ff7e8e53fd32b6b6326812c9 https://pubmed.ncbi.nlm.nih.gov/11001571 Zobrazit plný text záznamu Full Text from ScienceDirect