Single-cell analysis identifies a CD33
| Autor: | David J H F, Knapp, Colin A, Hammond, Tony, Hui, Marijn T J, van Loenhout, Fangwu, Wang, Nima, Aghaeepour, Paul H, Miller, Michelle, Moksa, Gabrielle M, Rabu, Philip A, Beer, Davide, Pellacani, R Keith, Humphries, Carl, Hansen, Martin, Hirst, Connie J, Eaves |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors Genotype Gene Expression Profiling Stem Cells Sialic Acid Binding Ig-like Lectin 3 Gene Expression Regulation Developmental Mitosis Mice Transgenic Cell Separation DNA Methylation Fetal Blood Flow Cytometry Phenotype Animals Humans Female Cord Blood Stem Cell Transplantation Single-Cell Analysis Transcriptome Biomarkers Cell Proliferation |
| Zdroj: | Nature cell biology. 20(6) |
| ISSN: | 1476-4679 |
| Popis: | Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested in cells identified uniquely by their ability to clonally regenerate detectable, albeit highly variable levels and types, of mature blood cells in serially transplanted recipients. From a multi-parameter analysis of the molecular features of very primitive human cord blood cells that display long-term cell outputs in vitro and in immunodeficient mice, we identified a prospectively separable CD33 |
| Databáze: | OpenAIRE |
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