Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear

Autor:	J J, Kim, R A, Rison, M S, Fanselow
Rok vydání:	1993
Předmět:	Brain Mapping Electroshock Neuronal Plasticity Conditioning Classical Long-Term Potentiation Association Learning Retention Psychology Fear Amygdala Hippocampus Receptors N-Methyl-D-Aspartate Rats Mental Recall Neural Pathways Animals Periaqueductal Gray Female
Zdroj:	Behavioral neuroscience. 107(6)
ISSN:	0735-7044
Popis:	The effects of amygdala, hippocampus, and periaqueductal gray (PAG) lesions on contextual fear conditioning in rats were examined. Freezing behavior served as the measure of conditioning. Unlesioned control animals showed reliable conditional freezing in the testing chamber when observed both immediately and 24 hr after footshocks. In contrast, rats with amygdala or ventral PAG lesions exhibited a significant attenuation in freezing both immediately and 24 hr after the shocks. Dorsal PAG lesions had no effect on freezing at either time. Animals with hippocampal lesions displayed robust freezing behavior immediately following the shock, even though they showed a marked deficit in freezing 24 hr after the shock. These results indicate that there are anatomically dissociable short- and long-term conditional fear states.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e3fbe25920d941d3b4b11d5c6e0f63f8 https://pubmed.ncbi.nlm.nih.gov/8136063 Zobrazit plný text záznamu