| Autor: |
Du, Lei, Wenbin, Li, Maxwell J, Tallman, Stephen M, Strakowski, Melissa P, DelBello, L, Rodrigo Patino, David E, Fleck, Su, Lui, Qiyong, Gong, John A, Sweeney, Jeffrey R, Strawn, Fabiano G, Nery, Jeffrey A, Welge, Emily, Rummelhoff, Caleb M, Adler |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(11) |
| ISSN: |
1740-634X |
| Popis: |
Disrupted topological organization of brain functional networks has been widely reported in bipolar disorder. However, the potential clinical implications of structural connectome abnormalities have not been systematically investigated. The present study included 109 unmedicated subjects with acute mania who were assigned to 8 weeks of treatment with quetiapine or lithium and 60 healthy controls. High resolution 3D-T1 weighted magnetic resonance images (MRI) were collected from both groups at baseline, week 1 and week 8. Brain networks were constructed based on the similarity of morphological features across brain regions and analyzed using graph theory approaches. At baseline, individuals with bipolar disorder illness showed significantly lower clustering coefficient (CName: Functional and Neurochemical Brain Changes in First-episode Bipolar Mania Following Successful Treatment with Lithium or Quetiapine. URL: https://clinicaltrials.gov/ .NCT00609193. Name: Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder. URL: https://clinicaltrials.gov/ .NCT00608075. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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