Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT

Autor:	Dawid, Gawliński, Irena, Smaga, Magdalena, Zaniewska, Kinga, Gawlińska, Agata, Faron-Górecka, Małgorzata, Filip
Rok vydání:	2019
Předmět:	Male Imipramine Thiazepines Brain Citalopram Antidepressive Agents Nucleus Accumbens Acetylcysteine Rats Benzamides Animals Autoradiography Receptor Serotonin 5-HT2A Carbamates Ketanserin Rats Wistar
Zdroj:	Pharmacological reports : PR. 71(6)
ISSN:	2299-5684
Popis:	There is a strong support for the role of serotonin (5-HT) neurotransmission in depression and in the mechanism of action of antidepressants. Among 5-HT receptors, 5-HTThe aim of the study was to investigate the effects of antidepressants, such as imipramine (15 mg/kg), escitalopram (10 mg/kg) and tianeptine (10 mg/kg) as well as drugs with antidepressant activity, including N-acetylcysteine (100 mg/kg) and URB597 (a fatty acid amide hydrolase inhibitor, 0.3 mg/kg) on the 5-HTSingle dose or chronic administration of imipramine decreased the radioligand binding in the claustrum and cortical subregions. The [In conclusion, the present result indicate different sensitivity of brain 5-HT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e3e834ad1c244ab0611b8ead5a862a83 https://pubmed.ncbi.nlm.nih.gov/31546158 Zobrazit plný text záznamu Full text from SpringerLink