Facile synthesis of pyrrolo[2,1-a]isoquinolines by domino reaction of 1-aroyl-3,4-dihydroisoquinolines with conjugated ketones, nitroalkenes and nitriles

Autor:	Grigorii S, Astakhov, Rinat R, Shigaev, Tatiana N, Borisova, Anastasia A, Ershova, Alexander A, Titov, Alexey V, Varlamov, Leonid G, Voskressensky, Maria D, Matveeva
Rok vydání:	2020
Předmět:	Ketones
Zdroj:	Molecular diversity. 25(4)
ISSN:	1573-501X
Popis:	A convenient protocol for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines with various electron-withdrawing substituents at C-2 atom is described. This approach is based on the two-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines with α,β-unsaturated ketones, nitroalkenes and acrylonitrile. Depending on the selected substrates, the reaction was performed in TFE under reflux or under microwave irradiation. Only for the two examples, a transition metal catalyst was used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e3c604a99f262ab4b5eb49d255d931de https://pubmed.ncbi.nlm.nih.gov/33040250 Zobrazit plný text záznamu Full text from SpringerLink