| Autor: |
Kattia, Núñez-Montero, Dorian, Rojas-Villalta, Leticia, Barrientos |
| Rok vydání: |
2022 |
| Zdroj: |
Frontiers in microbiology. 13 |
| ISSN: |
1664-302X |
| Popis: |
The antibiotic crisis is a major human health problem. Bioprospecting screenings suggest that proteobacteria and other extremophile microorganisms have biosynthetic potential for the production novel antimicrobial compounds. An Antarctic Sphingomonas strain (So64.6b) previously showed interesting antibiotic activity and elicitation response, then a relationship between environmental adaptations and its biosynthetic potential was hypothesized. We aimed to determine the genomic characteristics in So64.6b strain related to evolutive traits for the adaptation to the Antarctic environment that could lead to its diversity of potentially novel antibiotic metabolites.The complete genome sequence of the Antarctic strain was obtained and mined for Biosynthetic Gene Clusters (BGCs) and other unique genes related to adaptation to extreme environments. Comparative genome analysis based on multi-locus phylogenomics, BGC phylogeny, and pangenomics were conducted within the closest genus, aiming to determine the taxonomic affiliation and differential characteristics of the Antarctic strain.The Antarctic strain So64.6b showed a closest identity with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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