| Autor: |
M, Varbanova, K, Schütte, D, Kuester, M, Bellutti, I, Franke, J, Steinbach, H, Scheidbach, P, Malfertheiner |
| Jazyk: |
němčina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Deutsche medizinische Wochenschrift (1946). 136(36) |
| ISSN: |
1439-4413 |
| Popis: |
A 49-year-old man complained of increasing pain in the lower left abdomen. Three weeks previously joint pain had developed, and in the last 7 days the patient had noted a cutaneous rash at the lower legs. Within three days after admission a paralytic ileus developed, progressed and culminated in a small bowel perforation. In the 60 cm ileum specimen as well as in the skin lesions there was marked intra- und perivascular infiltration with neutrophil granulocytes and focal necrosis, but no granuloma.As the proteinase 3 subtype of antineutrophil cytoplasmic antibodies (ANCA) was positive ANCA-associated vasculitis with gastrointestinal, cutaneous and kidney involvement was diagnosed. After initiation of cytostatic treatment with methylprednisolone boli und cyclophosphamide the patient's condition improved. The post-operative course was uneventful.ANCA-associated vasculitis rarely presents with severe gastrointestinal complications. The disease represents an interdisciplinary challenge because of its variable clinical presentation and the possibly lethal outcome if not adequately treated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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