| Autor: |
S R, Chebabo, R J, Do-Carmo, H, Martins-Ferreira |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 21(3) |
| ISSN: |
0100-879X |
| Popis: |
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer Cl- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by diphenylhydantoin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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