| Autor: |
F, García, C, Roldán, I, López, N M, Martínez, M, Alvarez, M C, Bernal, J, Hernández, M C, Maroto |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Microbios. 103(404) |
| ISSN: |
0026-2633 |
| Popis: |
Hepatitis C virus (HCV) and hepatitis G virus (HGV) viraemia were investigated by RT-PCR protocols in peripheral blood mononuclear cells (PBMC) of 22 patients with chronic type C hepatitis. Samplings were at basal and 4-8 months after a 12 month period of treatment with interferon-alpha. A plus strand of HCV in PBMC was detected in 8 of 21 patients (38%) (p0.05; chi2 test) with a lack of response to therapy; a minus strand was detected in 10% of chronic type C hepatitis and 25% of the patients harboured HCV RNA in PBMC. The association with a response was nearly significant (p0.1; chi2 test). GBV-C/HGV RNA was detected in the serum of 9 of 21 (43%) patients and in PBMC of 20% of the patients viraemic. Genomic sequences of GBVC/HGV in PBMC were found, but further investigation is needed to assess the findings reported for HCV. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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