Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00031c

Autor:	Ballantine, Ross D., McCallion, Conor E., Nassour, Elie, Tokajian, Sima, Cochrane, Stephen A.
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Chemistry health care facilities manpower and services technology industry and agriculture equipment and supplies health care economics and organizations
Zdroj:	MedChemComm
ISSN:	2040-2511 2040-2503
Popis:	New tridecaptin analogues are cheaper to make and retain strong Gram-negative activity. Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e37942eda47919621e9365155edaa24a http://europepmc.org/articles/PMC6457190 Zobrazit plný text záznamu