The correlation between immunohistochemically-detected markers of angiogenesis and serum vascular endothelial growth factor in patients with breast cancer
| Autor: | Tilmann, Lantzsch, Lukas, Hefler, Ulf, Krause, Alexandra, Kehl, Christiiian, Goepel, Heinz, Koelbl, Juergen, Dunst, Dieter, Lampe |
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| Rok vydání: | 2002 |
| Předmět: |
Vascular Endothelial Growth Factor A
Lymphokines Neovascularization Pathologic Vascular Endothelial Growth Factors Receptor Protein-Tyrosine Kinases Breast Neoplasms Endothelial Growth Factors Immunohistochemistry Receptors Vascular Endothelial Growth Factor Biomarkers Tumor Linear Models Humans Female Receptors Growth Factor Neoplasm Staging |
| Zdroj: | Anticancer research. 22(3) |
| ISSN: | 0250-7005 |
| Popis: | As angiogenesis is known to be a crucial factor in breast cancer growth, numerous studies have examined angiogenic markers in breast cancer. Their definite role, however, has not been fully elucidated.We investigated intratumoral microvessel density (MVD), Vascular Endothelial Growth Factor (VEGF) and its receptor flk-1, and serum VEGF in 46 patients with breast cancer prior to surgery.Median serum VEGF in patients with breast cancer was 257.5 pg/mL (range, 21.9 to 899.6). Serum VEGF showed a significant correlation with tumor stage, but not with lymph node involvement, histological grade, estrogen and progesterone receptor status. Increased MVD was associated with advanced tumor stage (p=0.05) and high tumor grade (p0.001). A linear significant correlation between elevated serum VEGF and increased MVD was ascertained (p=0.02).Our results suggested that angiogenesis as reflected by immunohistochemically-detected MVD and serum VEGF, is involved in breast cancer growth and lymphatic spread. |
| Databáze: | OpenAIRE |
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