Resting and Exercise Energy Metabolism in Weight-Reduced Adults with Severe Obesity
| Autor: | Hames, Kazanna C., Coen, Paul M., King, Wendy C., Anthony, Steven J., Stefanovic-Racic, Maja, Toledo, Frederico G.S., Brown, Jolene, Helbling, Nicole, Dubé, John J., DeLany, James P., Jakicic, John J., Goodpaster, Bret H. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Diet Reducing Calorimetry Indirect macromolecular substances Middle Aged Lipid Metabolism Article Body Mass Index Obesity Morbid Cross-Sectional Studies Adipose Tissue Weight Loss Body Composition Humans Female Basal Metabolism Energy Metabolism Muscle Skeletal Exercise Life Style Oxidation-Reduction |
| Popis: | OBJECTIVE: To determine effects of physical activity (PA) with diet-induced weight loss on energy metabolism in adults with severe obesity. METHODS: Adults with severe obesity (n=11) were studied across 6mo of intervention, then compared to controls with less severe obesity (n=7) or normal weight (n=9). Indirect calorimetry measured energy metabolism during exercise and rest. Markers of muscle oxidation were determined by immunohistochemistry. Data are presented as medians. RESULTS: The intervention induced 7% weight loss (p=0.001) and increased vigorous PA by 24min/wk (p=0.02). During exercise, energy expenditure(EE) decreased, efficiency increased (p≤0.03), and fatty acid oxidation (FAO) did not change. Succinate dehydrogenase (SDH) increased (p=0.001), but fiber type remained the same. Post-intervention subjects’ resting metabolism remained similar to controls. Efficiency was lower in post-intervention subjects compared to normal weight controls exercising at 25W (p≤0.002) and compared to all controls exercising at 60%VO(2peak) (p≤0.019). Resting and exercise FAO of post-intervention subjects remained similar to adults with less severe obesity. SDH and fiber type were similar across all body weight statuses. CONCLUSIONS: While metabolic adaptations to PA during weight loss occur in adults with severe obesity, FAO does not change. Resulting FAO during rest and exercise remains similar to adults with less severe obesity. |
| Databáze: | OpenAIRE |
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