| Autor: |
Flávio, Alóe, Rosana Cardoso, Alves, John F, Araújo, Alexandre, Azevedo, Andrea, Bacelar, Márcio, Bezerra, Lia Rita Azeredo, Bittencourt, Guilherme, Bustamante, Tânia Aparecida Marchiori de Oliveira, Cardoso, Alan L, Eckeli, Regina Maria França, Fernandes, Leonardo, Goulart, Márcia, Pradella-Hallinan, Rosa, Hasan, Heidi Haueisen, Sander, Luciano Ribeiro, Pinto, Maria Cecília, Lopes, Gisele Richter, Minhoto, Walter, Moraes, Gustavo Antônio, Moreira, Daniela, Pachito, Mário, Pedrazolli, Dalva, Poyares, Lucila, Prado, Geraldo, Rizzo, R Nonato, Rodrigues, Israel, Roitman, Ademir Baptista, Silva, Stella Márcia Azevedo, Tavares |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 32(3) |
| ISSN: |
1516-4446 |
| Popis: |
This manuscript contains the conclusion of the consensus meeting on the diagnosis of narcolepsy based on the review of Medline publications between 1980-2010. Narcolepsy is a chronic disorder with age at onset between the first and second decade of life. Essential narcolepsy symptoms are cataplexy and excessive sleepiness. Cataplexy is defined as sudden, recurrent and reversible attacks of muscle weakness triggered by emotions. Accessory narcolepsy symptoms are hypnagogic hallucinations, sleep paralysis and nocturnal fragmented sleep. The clinical diagnosis according to the International Classification of Sleep Disorders is the presence of excessive sleepiness and cataplexy. A full in-lab polysomnography followed by a multiple sleep latency test is recommended for the confirmation of the diagnosis and co-morbidities. The presence of two sleep-onset REM period naps in the multiple sleep latency test is diagnostic for cataplexy-free narcolepsy. A positive HLA-DQB1*0602 with lower than 110pg/mL level of hypocretin-1 in the cerebrospinal fluid is required for the final diagnosis of cataplexy- and sleep-onset REM period -free narcolepsy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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