Tumor-Specific Endogenous Fe
| Autor: | Zhongxiong, Fan, Beili, Jiang, Qixin, Zhu, Sijin, Xiang, Li, Tu, Yifan, Yang, Qingliang, Zhao, Doudou, Huang, Jian, Han, Guanghao, Su, Dongtao, Ge, Zhenqing, Hou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug Carriers
Cell Survival Artesunate Mice Nude Antineoplastic Agents Gadolinium Hydrogen-Ion Concentration Magnetic Resonance Imaging Xenograft Model Antitumor Assays Theranostic Nanomedicine Rats Mice Methotrexate Cell Line Tumor Neoplasms Animals Humans Nanoparticles Ferrous Compounds Reactive Oxygen Species |
| Zdroj: | ACS applied materialsinterfaces. 12(13) |
| ISSN: | 1944-8252 |
| Popis: | Low drug payload and lack of tumor-targeting for chemodynamic therapy (CDT) result in an insufficient reactive oxygen species (ROS) generation, which seriously hinders its further clinical application. Therefore, how to improve the drug payload and tumor targeting for amplification of ROS and combine it with chemotherapy has been a huge challenge in CDT. Herein, methotrexate (MTX), gadolinium (Gd), and artesunate (ASA) were used as theranostic building blocks to be coordinately assembled into tumor-specific endogenous Fe |
| Databáze: | OpenAIRE |
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