Resuscitation with epinephrine worsens cerebral capillary no-reflow after experimental pediatric cardiac arrest: An

Autor: Onome A, Oghifobibi, Andrew E, Toader, Melissa A, Nicholas, Brittany P, Nelson, Nicole G, Alindogan, Michael S, Wolf, Anthony E, Kline, Seyed M, Nouraie, Corina O, Bondi, Bistra, Iordanova, Robert Sb, Clark, Hülya, Bayır, Patricia A, Loughran, Simon C, Watkins, Claudette M, St Croix, Patrick M, Kochanek, Alberto L, Vazquez, Mioara D, Manole
Rok vydání: 2023
Předmět:
Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(12)
ISSN: 1559-7016
Popis: Epinephrine is the principal resuscitation therapy for pediatric cardiac arrest (CA). Clinical data suggest that although epinephrine increases the rate of resuscitation, it fails to improve neurological outcome, possibly secondary to reductions in microvascular flow. We characterized the effect of epinephrine vs. placebo administered at resuscitation from pediatric asphyxial CA on microvascular and macrovascular cortical perfusion assessed using
Databáze: OpenAIRE