Macrophage Lxrα reduces atherosclerosis in Ldlr

Autor:	Yongjun, Yin, Silu, Zeng, Yanwei, Li, Zhou, Wu, Dajun, Huang, Peiyang, Gao
Rok vydání:	2020
Předmět:	Male Mice Knockout Transcriptional Activation ADP-Ribosylation Factors Macrophages Mice Transgenic Atherosclerosis Lipid Metabolism Plaque Atherosclerotic Cholesterol Receptors LDL Macrophages Peritoneal Animals Foam Cells Liver X Receptors
Zdroj:	Biochemical and biophysical research communications. 529(3)
ISSN:	1090-2104
Popis:	Liver X receptor alpha (Lxrα) is a sterol-regulated transcription factor that limits atherogenesis by regulating cholesterol homeostasis and inflammation in macrophages. Transcriptional profiling identified the reverse cholesterol transport protein Arf-like 7 (Arl7, Arl4c) as a Lxrα target gene. We hypothesized that the LXR response element (LXRE) sequence on the murine macrophage Arl7 promoter may play a critical role in Lxrα's atherosuppressive effects.Employing low density lipoprotein receptor-deficient mice with macrophage-specific Lxrα overexpression (LdlrLdlrLxrα's anti-atherosclerotic effects in Ldlr
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e2c1ebcff0721a5dabc643d4115f2403 https://pubmed.ncbi.nlm.nih.gov/32736671 Zobrazit plný text záznamu Full Text from ScienceDirect